Non-steroidal anti-inflammatory drugs inhibit the synthesis of prostaglandins in the kidney that support renal perfusion. If any If symptoms are abnormal, the dose should be reduced or the drug discontinued. When using Samasol to treat chronic symptoms, the following factors should be kept in mind: Long-term use of the drug should be regularly checked for tests such as liver function, blood count. Nabumetone should therefore be used with caution in patients with severe hepatic impairment. Since Nabumetone's metabolism to 6MNA is dependent on liver function, this may be reduced in patients with severe hepatic impairment. If liver function tests do not improve and worsen or develop systemic symptoms, discontinue use of Nabumetone. Jaundice and hepatitis have been reported with non-steroidal anti-inflammatory drugs. ![]() In patients with signs of impaired liver function or abnormal liver function tests, the progression and severity of hepatic impairment should be determined during treatment. As with other nonsteroidal anti-inflammatory drugs, Samasol may increase liver enzymes or other indicators of liver function. Discontinue Samasol if signs of gastrointestinal ulceration or bleeding appear. Monitor closely for abnormalities in the gastrointestinal tract. Samasol should be used with caution in patients with upper gastrointestinal disease or on anticoagulant therapy. Indications and contraindications to the drug Samasol 2.1. ![]() Besides, Nabumetone has a weak effect against collagen-induced platelet aggregation, but the drug does not affect bleeding time. Nabumetone does not affect the gastric mucosa, compared with other NSAIDs, Nabumetone is less likely to cause ulcers and gastrointestinal bleeding. However, Nabumetone, after being absorbed from the gastrointestinal tract, is rapidly metabolized in the liver to the active substance 6-methoxy-2-naphthylacetic acid (6-MNA), which is an active substance with strong inhibitory ability to prostaglandin synthesis. Nabumetone is a non-acidic prodrug that is a relatively weak inhibitor of prostaglandin synthesis. Nabumetone is a non-steroidal anti-inflammatory drug with anti-inflammatory, analgesic and antipyretic effects. The drug Samasol contains the main active ingredient, Nabumetone, which is prepared in the form of film-coated tablets with a strength of 500mg. Samasol is a non-steroidal anti-inflammatory drug (NSAIDs).
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